Daniel Lecoanet with Galina Bikzhanova and Robert West

UW-Madison Department of Chemistry

Indomethacin was altered through the addition of silane groups to create novel drugs for cancer treatment. Both Indomethacin silane amines and Indomethacin silane esters were synthesized, resulting in a variety of compounds, the details of which are discussed. Because purity is a concern in both effective drug testing and in drugs themselves, various methods of purification were used, such as distillation, solvent extraction, and recrystallization. All products were characterized using 1H NMR spectroscopy.